Courses
30100. Biochemistry and Molecular Biology
Meredith, Philipson, Epstein
The physical properties of amino acids, proteins, carbohydrates, and lipids
are related to the major metabolic pathways to illustrate principles of
biochemical regulation. Emphasis is placed on enzyme mechanisms and compartmentalization
of molecules and cofactors as key elements in regulation. Prereq: Two
quarters of organic chemistry.
30400. Protein Fundamentals
Piccirilli, Correll
The physico-chemical phenomena that define protein structure and function.
Topics include 1) the interactions/forces that define polypeptide conformation;
2) the principles of protein folding, structure and design; and 3) the
concepts of molecular motion, molecular recognition, and enzyme catalysis.
Prereq: BMB 30100.
30500. Fundamentals of Structural Biology
Kossiakoff, Koide
This course emphasizes the basic principles of protein structure determination
by X-ray crystallography and NMR spectroscopy. The underlying physical
concepts of these methods will be introduced and the capabilities of each
will be discussed and compared in context of their uses in de novo structure
determination and protein engineering studies.
30600. Nucleic Acid Structure and Function
Correll
This course focused on the biochemistry of nucleic acids. Topics include
nucleic acid structure and chemistry, protein-nucleic acid interactions,
and the enzymology of key processes such as DNA repair and recombination,
RNA splicing, and protein synthesis. A special emphasis is placed on primary
literature and experimental design. Autumn, Prereq: Courses in Biochemistry,
molecular biology and organic chemistry.
31000. Fundamentals in Molecular Biology (=MGCB 31000)
Storb, Staley
Nucleic acid structure and DNA technology, DNA replication, DNA damage,
muta-genesis and repair, Transposons and site-specific recombination,
prokaryotic and eukaryotic transcription and its regulation, RNA
structure, splicing and catalytic RNAs and protein synthesis.
31200. Molecular Biology I (=MGCB 31200)
Rothman-Denes
Nucleic acid structure, mechanisms of transcription, replication, and
recombination
and their regulation in prokaryotes and eukaryotes. Prereq: Consent of
instructor.
31300. Molecular Biology II: Eukaryotic
Gene Expression. Transcriptional and Posttranscriptional Regulation. (=MGCB
31300)
Singh, Staley
Analysis of regulatory pathways and mechanisms involved in the control
of eukaryotic gene activity. Prereq: BMB 31200 or consent of instructor.
31400. General Principles of Genetic Analysis (=MGCB 31400)
Preuss, Bishop, Lahn
Coverage of the fundamental tools of genetic analysis as used to study
biological phenomena. Topics include genetic exchange in prokaryotes,
eukaryotes, and their viruses and plasmids; principles of transformation;
analysis of gene function. Prereq: Undergraduate genetics or consent of
instructors.
31500. Genetic Mechanisms (=MGCB 31500)
Esposito, Bishop
Advance coverage of genetic mechanisms, including genetic analysis of
molecular mechanisms in meiosis and mitosis; recombination mechanisms;
and genetics of transposons. Prereq: BMB 31400.
31600. Cell Biology I (=MGCB 31600)
Turkewitz, Glick
A lecture/discussion course on fundamentals of protein synthesis and translocation,
protein and membrane sorting and transport, organelle biogenesis, and
the cytoskeleton.
31700. Cell Biology II (=MGCB 31700)
Lamppa
Chromatin structure and its role in transcription, communication between
nucleus and cytoplasm, translation, protein folding and assembly, molecular
chaperones, elements of signal transduction, homeostasis, growth control
and the cell cycle, cytoarchitecture, cell adhesion and migration.
31900. Introduction to Faculty Research (=MGCB 31900)
Staff
Introduction to scientific literature, scientific writing, and the development
of ideas in
laboratory research by departmental and other invited speakers. A required
course
for students in BMB.
32100. Designer Proteins and Peptides
Meredith
This graduate level course will deal with the design, synthesis, and characterization
of novel non-natural proteins and peptides. Some specific topics included
are the following: Peptide models of transmembrane domains, membrane fusion
and membrane binding proteins, apolipoproteins, and peptide hormones.
Side chain modified peptides and proteins, peptide backbone modified peptides,
covalent lipid-peptide and nucleotide-peptide adducts, peptide block copolymers,
e.g., PEG-peptides, synthetic supersecondary structures, including 4-
and 6-helix bundles, synthetic bab structures, and template assisted folding
of b-sheet structures. Readings would consist of entirely of journal articles.
32200. Introduction to Biophysical Methods
Sosnick
Exposes students to modern biophysical methods and provides background
for use of existing facilities at the University of Chicago. Topics include
the measurement of physical properties of biological molecules including
structure, thermodynamics, and kinetics. The primary focus is on practical
aspects but covers a sufficient amount of theoretical background for the
proper understanding of the technique. Prereq: BMB 30500 or consent of
instructor.
32300. Macromolecular Function
Kent, Moffat
This course presents a series of advanced case studies designed to familiarize
students with current protein research and to expand on the protein fundamentals
taught in Biochemistry 30400. Topics include: post-translational modification
of proteins; protein-protein interactions; principles of enzyme catalysis;
natural inhibitors of enzyme action; integral membrane proteins and ion
channels; molecular motors; allosteric phenomena; conversion of light
energy in photosynthesis. Prereq: BMB 30400 or equivalent.
32400. Molecular Biophysics
Makinen
An introductory course emphasizing concepts of physical chemistry and
physics in the interactions of biological macromolecules with particular
focus on electrostatic, hydrophobic, and hydrogen bonding interactions
in proteins and the role of diffusion and transport in biological processes.
Prereq: Biochemistry or two courses in organic chemistry and physical
chemistry or physics.
39800. Selected Topics in Biochemistry and Molecular Biology
Staff
Subject matter for individual tutorial-based study is selected through
prior consultation and is given under the guidance of a faculty member.
The student and faculty member must indicate at time of registration whether
the course will be taken on a letter grade or pass/fail basis. Prereq:
Consent of department and instructor.
39900. Introduction to Research
Staff
The student participates in one of the research programs of the department.
Prereq: Consent of Department Chair and individual faculty member.
40100. Research in Biochemistry and Molecular Biology
Staff
The student conducts original investigation under the direction of a faculty
member. Prereq: Completion of course requirements and qualifying examination
at the Ph.D. level and approval of the chair of the department.
8/29/03
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