Courses
30800. Cancer Biology I: Introduction to Cancer Biology
Conzen, Imamoto, Manaligod
Overview of cancer biology, including epidemiology, pathology, diagnosis
and staging, the basis for various therapeutic strategies, and the conduct
of Phase I, II, and III clinical trials. Also covered are experimental
models for cancer, including the generation and validation of animal models.
The course emphasizes several tumor models, such as breast cancer, hematological
malignancies, cervical carcinoma, colon carcinoma, and sarcomas.
30900. Cancer Biology II: Molecular Mechanisms of Cancer (=PATH 30900)
Rudin, Le Beau, Frank
Examines our current understanding of the processes leading to malignant
cell transformation. Topics include comparative properties of normal cells
and cells transformed spontaneously or by chemicals, radiation, or viruses;
multistage mechanisms of carcinogenesis; genetic basis of cancer; oncogenes
and tumor suppressor genes; metabolic activation of chemical carcinogens;
DNA adduct formation; repair of DNA damage; metastasis/invasion; and mechanisms
of cancer therapeutics.
31200. Cancer Biology III: Signal Transduction and Cell Cycle Regulation
(=NPHP 32100, CPHY 31200)
Du, Lin
Topics include receptor ligands, membrane receptor tyrosine kinases and
phosphatases, G proteins, proto-oncogenes, signaling pathways, cytoplasmic
protein kinases and phosphatases, transcription factors, receptor-nucleus
signaling, development and cancer, genetic dissection of signaling pathways,
oncogenes and tumor suppressor genes, cell growth and cell proliferation,
interplay of cell cycle regulators, cell cycle progression and apoptosis.
31300-01. Cancer Biology IV: Frontiers in Cancer Research
Rinker-Schaeffer
A lecture-discussion course focusing on metastatic progression, tumor
invasion, and experimental animal models and systems. Students are expected
to write and present a research proposal based on one of the topics presented.
(alternating years).
31300-03. Cancer Biology IV: Frontiers in Cancer Research
Dolan
Covers experimental therapeutics and examines molecular targets in cancer
therapy. Topics include DNA as a target, topoisomerase inhibitors, metastases
and invasion, angiogenesis, growth factors, drug resistance, pharmacogenetics,
immunotherapy, and chemopreventive agents. Students are expected to write
and present a research proposal based on one of the topics presented.
(alternating years).
39000. Cancer Biology V: Introduction to Experimental Cancer Biology
Peter, Franzoso
This course is linked to the seminar series sponsored by the Committee
on Cancer Biology and also incorporates seminars of interest from other
Cluster programs. Typically, students meet to discuss research papers
published by the following week’s seminar speaker, attend the seminar,
and then meet with the speaker afterward. The goal of the course is to
broaden the student’s exposure to current research and to encourage
discussion of scientific ideas among peers.
39900. Readings in Cancer Biology
Staff
Reading course on various topics in cancer biology.
40100. Research: Cancer Biology
Le Beau and Staff
This list was last revised on 9/08/2003.
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