Courses
Biochemistry
CPHY 31200. Signal Transduction and Cell Cycle Regulation (=CABI 31200,
NPHP 31200). Spring
Du, Lin
Topics include receptor ligands, receptor tyrosine kinases and phosphatases,
G protein-coupled receptors, signaling pathways, cytoplasmic protein kinases
and phosphatases, receptor-nucleus signaling, nuclear proto-oncogenes,
cell growth suppression, tumor suppressors, regulation of cell cycle progression,
modulation of cell cycle progression and apoptosis.
CPHY 31900. Molecular Mechanisms of Cell Signaling (=NURB 31900)
Tang
Cells in the body communicate with each other by a variety of extracellular
signals (e.g., hormones, neurotransmitters) and processes such as vision
and olfaction, as well as diseases such as cancer, all involve aspects
of such signaling processes. The subject matter of this course considers
molecular mechanism of the wide variety of intracellular mechanisms that,
when activated, change cell behavior. Both general and specific aspects
of intracellular signaling are covered in the course, with an emphasis
on the structural basis of cell signaling. Offered alternate years.
CPHY 33600. Cell Signaling (=NPHP 33600). Autumn
Palfrey
Cells in the body communicate with each other by a variety of extracellular
signals (e.g., hormones and neurotransmitters) that are disseminated locally
or in the bloodstream to distant targets. What happens when these signals
are received by the target cells? The subject matter of this course considers
the wide variety of intracellular mechanisms that, when activated, change
cell behavior. Both general and specific aspects of intracellular signaling
are covered in the course, the latter including detailed discussions of
receptors, G-proteins, cyclic nucleotides, calcium and calcium-binding
proteins, phosphoinositides, protein kinases, and phosphatases. C. Prereq:
BIOS 20200 and 20181, or BIOS 20191.
BCMB 30100. Basic Biochemistry and Molecular Biology. Autumn
Meredith, Philipson
The course is intended as an introduction to biochemistry and molecular
biology for first year graduate students, first year medical students,
and advanced undergraduates. It has three sections. The first is the structure
and function of macromolecules (proteins, including enzymes, and nucleic
acids) and supramolecular aggregates such as biological membranes. The
second section is on cellular metabolism, emphasizing enzymatic mechanisms,
cellular compartmentalization, and integration of metabolic systems. The
third is the beginning of molecular biology of the gene, emphasizing DNA
replication, transcription, and translation. Prereq: Two quarters of organic
chemistry.
BCMB 30400. Protein Fundamentals. Autumn
Piccirilli, Corell
The physico-chemical phenomena that define protein structure and function.
Topics include 1) the interactions/forces that define polypeptide conformation;
2) the principles of protein folding, structure and design; and 3) the
concepts of molecular motion, molecular recognition, and enzyme catalysis.
Prereq: BCMB 30100.
30099. Readings in Cell Physiology
Staff
Reading courses on various topics in cell physiology.
40001. Research in Cell Physiology
Staff
Research credit (varied units) for research undertaken by graduate students
under the guidance of a faculty member of the Committee on Cell Physiology.
Cell Biology
MGCB 31600. Cell Biology. Autumn
Turkewitz, Glick, Miller
Eukaryotic protein traffic and related topics, including molecular motors
and cytoskeletal dynamics, organelle architecture and biogenesis, protein
translocation and sorting, compartmentalization in the secretory pathway,
endocytosis and exocytosis, and mechanisms and regulation of membrane
fusion.
MGCB 31700. Advanced Cell Biology. Winter
Lamppa
Chromatin structure and its role in transcription, communication between
nucleus and cytoplasm, translation, protein folding and assembly, molecular
chaperones, elements of signal transduction, homeostasis, growth control
and the cell cycle, cytoarchitecture, cell adhesion and migration.
NPHP 31800. Cellular Neurobiology (=NURB 31800). Autumn
Lloyd
The cell biology of neurons is considered, with emphasis on intracellular
and intercellular communication and regulation. Simple neuronal systems,
especially those of invertebrates, are analyzed from a functional viewpoint.
Molecular Biology
MGCB 31000. Fundamentals in Molecular Biology. Winter
Storb, Staley
The course covers nucleic acid structure and DNA topology, recombinant
DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons
and site-specific recombination, prokaryotic and eukaryotic transcription
and its regulation, RNA structure, splicing and catalytic RNAs, protein
synthesis, and chromatin.
MGCB 31200. Molecular Biology I. Winter
Rothman-Denes
Nucleic acid structure; mechanisms of transcription, replication, and
recombination and their regulation in prokaryotes and eukaryotes.
MGCB 31300. Molecular Biology II. Spring
Singh, Staley
Analysis of regulatory pathways and mechanisms involved in the control
of eukaryotic gene activity.
Physiology
CPHY 30300. Cell and Organ Physiology (=MBIO 30300; NPHP 30300), Autumn.
Palfrey and Staff
Membrane and cell physiology; muscle, cardiovascular, and gastrointestinal
physiology.
CPHY 30400. Organ Physiology and Endocrinology (=MBIO 30400; NPHP 30400),
Winter.
Chang and Staff
Renal, respiratory, endocrine and reproductive physiology and the regulation
of metabolism.
CPHY 31500. Vertebrate Neural Systems (=NURB 31500). Autumn
Ragsdale and Staff
This lab-centered course teaches students the fundamental principles of
mammalian neuroanatomy. Students learn the major structures and the basic
circuitry of the CNS and PNS. Somatic, visual, auditory, vestibular and
olfactory sensory systems are presented in particular depth.
CPHY 33200. Ionic Channels and Excitable Membranes (=NPHP 33200; CPNS
33200). Winter
Nelson, Hanck
A review of the voltage-gated and ligand-gated channels, including the
functional role(s) of the channels in cell behavior and biophysical aspects
of ion transport through channels. Correlation is made between known channel
protein structure and channel functional characteristics, including gating,
block and drug-related changes in channel current kinetics.
Genetics
MGCB 31400. General Principles of Genetic Analysis. Autumn
Preuss, Bishop, Lahn
Coverage of the fundamental tools of genetic analysis as used to study
biological phenomena. Topics include genetic exchange in prokaryotes,
eukaryotes, and their viruses and plasmids; principles of transformation;
analysis of gene function.
MGCB 31500. Genetic Mechanisms. Autumn
Esposito, Bishop
Advanced coverage of genetic mechanisms involved in genome stability and
rearrangement. Topics include genetics of transposons, site-specific recombination,
gene conversion, reciprocal crossing over, and plasmid and chromosome
segregation.
HGEN 46900. Human Genetics II. Human Variation and Disease. Autumn
DiRienzo, Hudson, Pritchard
This course focuses on principles of population genetics and complex trait
mapping
as they apply to humans. It will include the discussion of genetic variation
and disease mapping data.
HGEN 47000. Human Genetics I. Mechanisms of Human Disease. Spring
Ober, Millen, Lese-Martin, McNally, Carlson
This course covers classical and modern approaches to studying cytogenetic,
Mendelian, and complex human diseases. Topics include chromosomal structure,
human gene discovery for single gene and complex diseases, non-Mendelian
inheritance, mouse models of human disease, cancer genetics, and human
population genetics. The format includes lectures and student presentations.
Other courses of interest:
31900. Molecular Mechanisms of Cell Signaling (=CPHY 31900)
Tang
Cells in the body communicate with each other by a variety of extracellular
signals (e.g., hormones, neurotransmitters) and processes such as vision
and olfaction, as well as diseases such as cancer, all involve aspects
of such signaling processes. The subject matter of this course considers
molecular mechanism of the wide variety of intracellular mechanisms that,
when activated, change cell behavior. Both general and specific aspects
of intracellular signaling are covered in the course, with an emphasis
on the structural basis of cell signaling. Offered alternate years.
35100. Biophysical Discussions. Spring
Staff
Seminar/discussion course led by faculty in the Physical Sciences Division
and the Biological Sciences Division to present a mix of questions, data
and speculations centering on a common theme. Past quarterly topics have
been proteins, membranes and nucleic acids.
This list was last revised on 8/29/2003.
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