Courses
Biochemistry
BCMB 30400. Protein Fundamentals. Autumn
Piccirilli, Corell
The physico-chemical phenomena that define protein structure and function.
Topics include 1) the interactions/forces that define polypeptide conformation;
2) the principles of protein folding, structure and design; and 3) the
concepts of molecular motion, molecular recognition, and enzyme catalysis.
Prereq: BCMB 30001.
BCMB 30100. Basic Biochemistry and Molecular Biology. Autumn
Meredith, Philipson
The course is intended as an introduction to biochemistry and molecular
biology for first year graduate students, first year medical students,
and advanced undergraduates. It has three sections. The first is the structure
and function of macromolecules (proteins, including enzymes, and nucleic
acids) and supramolecular aggregates such as biological membranes. The
second section is on cellular metabolism, emphasizing enzymatic mechanisms,
cellular compartmentalization, and integration of metabolic systems. The
third is the beginning of molecular biology of the gene, emphasizing DNA
replication, transcription, and translation. Prereq: Two quarters of organic
chemistry.
NPHP 31200. Signal Transduction and Cell Cycle Regulation (=CABI 31200,
CPHY 31200). Spring
Du, Lin
Topics include receptor ligands, receptor tyrosine kinases and phosphatases,
G protein-coupled receptors, signaling pathways, cytoplasmic protein kinases
and phosphatases, receptor-nucleus signaling, nuclear proto-oncogenes,
cell growth suppression, tumor suppressors, regulation of cell cycle progression,
modulation of cell cycle progression and apoptosis.
3NPHP 33600. Cell Signaling (=CPHY 33600). Autumn
Palfrey
Cells in the body communicate with each other by a variety of extracellular
signals (e.g., hormones and neurotransmitters) that are disseminated locally
or in the bloodstream to distant targets. What happens when these signals
are received by the target cells? The subject matter of this course considers
the wide variety of intracellular mechanisms that, when activated, change
cell behavior. Both general and specific aspects of intracellular signaling
are covered in the course, the latter including detailed discussions of
receptors, G-proteins, cyclic nucleotides, calcium and calcium-binding
proteins, phosphoinositides, protein kinases, and phosphatases. C. Prereq:
BIOS 20200 and 20181, or BIOS 20191.
Cell Biology
MGCB 31600. Cell Biology. Autumn
Turkewitz, Glick, Miller
Eukaryotic protein traffic and related topics, including molecular motors
and cytoskeletal dynamics, organelle architecture and biogenesis, protein
translocation and sorting, compartmentalization in the secretory pathway,
endocytosis and exocytosis, and mechanisms and regulation of membrane
fusion.
MGCB 31700. Advanced Cell Biology. Winter
Lamppa
Chromatin structure and its role in transcription, communication between
nucleus and cytoplasm, translation, protein folding and assembly, molecular
chaperones, elements of signal transduction, homeostasis, growth control
and the cell cycle, cytoarchitecture, cell adhesion and migration.
NPHP 31800. Cellular Neurobiology (=NURB 31800). Autumn
Lloyd
The cell biology of neurons is considered, with emphasis on intracellular
and intercellular communication and regulation. Simple neuronal systems,
especially those of invertebrates, are analyzed from a functional viewpoint.
Molecular Biology
MGCB 31000. Fundamentals in Molecular Biology. Winter
Storb, Staley
The course covers nucleic acid structure and DNA topology, recombinant
DNA technology, DNA replication, DNA damage, mutagenesis and repair, Transposons
and site-specific recombination, prokaryotic and eukaryotic transcription
and its regulation, RNA structure, splicing and catalytic RNAs, protein
synthesis, and chromatin.
MGCB 31200. Molecular Biology I. Winter
Rothman-Denes
Nucleic acid structure; mechanisms of transcription, replication, and
recombination and their regulation in prokaryotes and eukaryotes.
MGCB 31300. Molecular Biology II. Spring
Singh, Staley
Analysis of regulatory pathways and mechanisms involved in the control
of eukaryotic gene activity.
Physiology
NPHP 33200. Ionic Channels and Excitable Membranes (=CPHY 33200). Winter
Nelson, Hanck
A review of the voltage-gated and ligand-gated channels, including the
functional role(s) of the channels in cell behavior and biophysical aspects
of ion transport through channels. Correlation is made between known channel
protein structure and channel functional characteristics, including gating,
block and drug-related changes in channel current kinetics.
NPHP 30300. Cell and Organ Physiology. Autumn.
Palfrey and Staff
Membrane and cell physiology; muscle, cardiovascular, and gastrointestinal
physiology.
NPHP 30400. Organ Physiology and Endocrinology. Winter.
Chang and Staff
Renal, respiratory, endocrine and reproductive physiology and the regulation
of metabolism.
NURB 31500. Vertebrate Neural Systems (=NURB 31500). Autumn
Ragsdale and Staff
This lab-centered course teaches students the fundamental principles of
mammalian neuroanatomy. Students learn the major structures and the basic
circuitry of the CNS and PNS. Somatic, visual, auditory, vestibular and
olfactory sensory systems are presented in particular depth. In addition,
students select two courses in pharmacology.
Pharmacology
NPHP 32200. Molecular Neurobiology (=NURB 32200)
Green and McGehee
Current research in the molecular biology of the nervous system, i.e.,
the structure and function of macromolecules that control, propagate,
and elicit neural signaling. Topics covered include (1) structural elements
of neurons and glia; (2) structure and function of the synapse; (3) aspects
of the molecular basis of neural signaling; and (4) gene expression in
neural systems. Lectures draw on current journal literature to present
a state-of-the-art background of the topic, the current questions being
explored, as well as problems and aspects.
NPHP 32800. Neuropsychopharmacology II
Vezina
Effects of drugs on behavior; emphasis on the functional contribution
of brain neurotransmitter systems.
Other courses offered by the Dept of Neurobiology, Pharmacology and Physiology
30600. Pharmacology
Staff
The principles of drug action.
30700. Introduction to Therapeutics
Murphy and Staff
The therapeutic indications for drugs with emphasis on their pharmacological
basis of action and potential side effects.
32900. Perspectives in Drug Abuse
deWit and Staff.
Opioids, psychomotor stimulants, alcohol, barbiturates, nicotine and hallucinogens,
with regard to history, abuse liability, use pattern, neuropharmacology,
psychopharmacology, and sequalae of use/abuse.
33400. Genetics in Neuropharmacology
Zhuang
This course focuses on diverse genetic approaches in pharmacology research.
Topics are organized by genetic approaches including knockout, transgenic,
knock-in, tissue-specific knockout, inducible strategies, forward genetics,
pharmacogenomics and gene therapy. The selection of papers aims to cover
different neurotransmitter systems and signaling pathways.
34000. Neurodegenerative Diseases
Thinakaran
The course will introduce students to the molecular and cellular mechanisms
involved in a number of neurodegenerative diseases. This course will provide
an overview of the fundamental concepts of neurodegeneration and focus
on the recent advances in select disorders. The current literature on
Alzheimer's disease, Parkinson's disease, Huntington's disease and motor
neuron diseases will be discussed in greater detail. The primary focus
of the course is to explore the mechanisms (such as protein misfolding)
underlying neuronal dysfunction and death.
38600. Readings in Neurobiology
Schwartz
39900. Readings in Pharmacology
Staff
40100. Research in Pharmacology
Staff
Research credit (varied units) for research undertaken by graduate students
under the guidance of a faculty member of the Department of Neurobiology,
Pharmacology and Physiology.
This list was last revised on 8/29/2003.
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